Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?

Highlights • Conserved epitopes on the influenza HA protein offer broad protection. • Antibodies specific for these conserved epitopes are induced by exposure to antigenically distinct strains. • Immune history directly determines the likelihood of generating a broadly protective response. • Current...

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Bibliographic Details
Published in:Current opinion in immunology 2016-10, Vol.42, p.48-55
Main Authors: Neu, Karlynn E, Henry Dunand, Carole J, Wilson, Patrick C
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
B-Lymphocytes - immunology
B-Lymphocytes - virology
Hemagglutinin Glycoproteins, Influenza Virus - metabolism
Humans
Immunodominant Epitopes - metabolism
Immunologic Memory
Influenza A virus - immunology
Influenza Vaccines - immunology
Influenza, Human - immunology
Influenza, Human - prevention & control
Orthomyxoviridae
Vaccination
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Summary:Highlights • Conserved epitopes on the influenza HA protein offer broad protection. • Antibodies specific for these conserved epitopes are induced by exposure to antigenically distinct strains. • Immune history directly determines the likelihood of generating a broadly protective response. • Current vaccine trials are underway to harness this response with the realistic goal of eradicating seasonal influenza strains.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2016.05.012