Amlodipine-induced gingival overgrowth in a child after liver transplant

Drug-induced gingival overgrowth (GO) has been associated with phenytoin, cyclosporine, and calcium channel blocker therapies. This study reports the case of an 11-year-old girl who was referred for evaluation of GO, which had occurred over the last 6 months. Her medical history included a liver tra...

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Bibliographic Details
Published in:Autopsy & case reports 2016-09, Vol.6 (3), p.47-51
Main Authors: Guollo, André, Vivas, Ana Paula Molina, Lopes, Rodrigo Nascimento, Porta, Gilda, Alves, Fábio Abreu
Format: Article
Language:English
Subjects:
Clinical Case Report
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Summary:Drug-induced gingival overgrowth (GO) has been associated with phenytoin, cyclosporine, and calcium channel blocker therapies. This study reports the case of an 11-year-old girl who was referred for evaluation of GO, which had occurred over the last 6 months. Her medical history included a liver transplant due to biliary atresia 3 years ago, immunosuppressive therapy, and hypertension, which is why she was started on a daily intake of amlodipine. The intraoral examination showed generalized GO, and the treatment consisted of a gingivectomy. Subsequently, amlodipine was replaced with captopril and oral hygiene instructions. There was no recurrence of GO after 28 months of follow-up. Although GO may be related to the chronic use of amlodipine, such an association is uncommon in pediatrics, and the treatment consists of the replacement of medication combined with a surgical approach and plaque control.
ISSN:2236-1960
DOI:10.4322/acr.2016.041