Surgical immune interventions for solid malignancies

Structured Abstract Background The purpose of this study was to systematically review clinically translatable immunotherapeutic agents that are delivered regionally for solid malignancies. Data Sources PubMed and ClinicalTrials.gov were searched for published and registered clinical trials, respecti...

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Bibliographic Details
Published in:The American journal of surgery 2016-10, Vol.212 (4), p.682-690.e5
Main Authors: Zeltsman, Masha, DO, Mayor, Marissa, MD, Jones, David R., MD, FACS, Adusumilli, Prasad S., MD, FACS, FCCP
Format: Article
Language:English
Subjects:
Adenoviruses
Adoptive cell therapy
Antibodies, Monoclonal - therapeutic use
Antigens
BCG Vaccine
Catheterization
Clinical trials
Clinical Trials as Topic
Colorectal cancer
Combined Modality Therapy
Cytokines
Cytotoxicity
Dendritic cells
Gangrene
Gastric cancer
Granulocytes
Humans
Immune system
Immunotherapy
Immunotherapy - methods
Injections, Intralesional
Iodine
Laparoscopy
Liver cancer
Lung cancer
Lymphocytes
Melanoma
Mesothelioma
Metastasis
Neoplasms - pathology
Neoplasms - therapy
Ovarian cancer
Patients
Pharmaceutical industry
Regional immunotherapy
Studies
Surgery
Surgical immunotherapy
Tumor Microenvironment
Tumor necrosis factor-TNF
Tumors
Vaccines
Vascular Access Devices
Vectors (Biology)
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Summary:Structured Abstract Background The purpose of this study was to systematically review clinically translatable immunotherapeutic agents that are delivered regionally for solid malignancies. Data Sources PubMed and ClinicalTrials.gov were searched for published and registered clinical trials, respectively. The search yielded 334 relevant publications, of which 116 manuscripts were included for review after exclusion criteria were applied. Conclusions There has been an increase in the regional administration of cell-based and viral vector-based clinical trials over the last 5 years. Surgical interventions have been developed for intrapleural, intracranial, intraperitoneal, and intratumoral routs of access to enhance the local delivery of there therapies. Multimodality therapies that combine regional immunotherapy with other local and systemic therapies are demonstrating continued growth as the field of immunotherapy continues to expand.
ISSN:0002-9610
1879-1883
DOI:10.1016/j.amjsurg.2016.06.008