Prevalence and Clinicopathological Features of Triaditis in a Prospective Case Series of Symptomatic and Asymptomatic Cats

• Published in: Journal of veterinary internal medicine 2016-07, Vol.30 (4), p.1031-1045
• Main Authors: Fragkou, F.C., Adamama‐Moraitou, K.K., Poutahidis, T., Prassinos, N.N., Kritsepi‐Konstantinou, M., Xenoulis, P.G., Steiner, J.M., Lidbury, J.A., Suchodolski, J.S., Rallis, T.S.
• Format: Article
• Language: English
• Subjects: Animals; Cat; Cat Diseases - pathology; Cats; Cholangitis; Cholangitis - complications; Cholangitis - pathology; Cholangitis - veterinary; Fatty Liver - pathology; Fatty Liver - veterinary; Inflammatory Bowel Disease; Inflammatory Bowel Diseases - complications; Inflammatory Bowel Diseases - pathology; Inflammatory Bowel Diseases - veterinary; Pancreatitis; Pancreatitis - complications; Pancreatitis - pathology; Pancreatitis - veterinary; SMALL ANIMAL
• ISSN: 0891-6640; 1939-1676
• DOI: 10.1111/jvim.14356

Background The term triaditis designates the concurrent presence of idiopathic inflammatory bowel disease (IBD), cholangitis, and pancreatitis in cats. Hypothesis/Objectives The histopathology of concurrent, but often subclinical, inflammatory processes in the small intestine, liver, and pancreas of cats is poorly described. We aimed to investigate the frequency of enteritis, cholangitis, pancreatitis, or some combination of these in symptomatic and asymptomatic cats, compare clinicopathological features, and correlate histopathological with laboratory findings. Animals Domestic cats (27 symptomatic, 20 asymptomatic, and 8 normal). Methods Prospective study. Physical examination, laboratory variables (CBC, serum biochemistry profile, serum thyroxine concentration, serum feline trypsin‐like immunoreactivity [fTLI], feline lipase immunoreactivity [fPLI, as measured by Spec fPL®], urinalysis, and fecal analysis), imaging, and histopathological examinations were conducted. Feline liver, pancreas, and small intestine were biopsied during laparotomy. Results Inflammatory lesions were detected in 47 cats (27 symptomatic, 20 asymptomatic). In total, 20 cats had histopathologic lesions of IBD (13/47, 27.7%), cholangitis (6/47, 12.8%), or pancreatitis (1/47, 2.1%) alone, or inflammation involving >1 organ (27/47, 57.4%). More specifically, 16/47 cats (34.0%) had concurrent lesions of IBD and cholangitis, 3/47 (6.4%) of IBD and pancreatitis, and 8/47 cats (17%) of triaditis. Triaditis was identified only in symptomatic cats (8/27, 29.6%). A mild, positive correlation was detected between the severity (score) of IBD lesions and the number of comorbidities (rho = +0.367, P = .022). Conclusions and Clinical Importance Histopathological evidence of IBD or IBD with comorbidities was detected in both symptomatic and asymptomatic cats. The possibility of triaditis should be considered in symptomatic cats with severe IBD.