Investigation of cyclin D1 rs9344 G>A polymorphism in colorectal cancer: a meta-analysis involving 13,642 subjects

The relationship between ( ) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed...

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Bibliographic Details
Published in:OncoTargets and therapy 2016, Vol.9, p.6641-6650
Main Authors: Qiu, Hao, Cheng, Chengguo, Wang, Yafeng, Kang, Mingqiang, Tang, Weifeng, Chen, Shuchen, Gu, Haiyong, Liu, Chao, Chen, Yu
Format: Article
Language:English
Subjects:
Breast cancer
Cell cycle
Colorectal cancer
Cyclin-dependent kinases
Hospitals
Meta-analysis
Mortality
Original Research
Phase transitions
Polymerase chain reaction
Polymorphism
Proteins
Studies
Surgery
Thoracic surgery
White people
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Summary:The relationship between ( ) rs9344 G>A polymorphism and colorectal cancer (CRC) risk is still ambiguous. To obtain a precise estimation of the relationship, we performed an extensive meta-analysis based on the eligible studies. Crude odds ratios with their 95% confidence intervals were harnessed to determine the strength of correlation between rs9344 G>A polymorphism and CRC risk under the allele, the homozygote, the dominant, and the recessive genetic models, respectively (28 studies with 5,784 CRC cases and 7,858 controls). Our results indicated evidence of the association between rs9344 G>A polymorphism and the increased risk of CRC in four genetic models: A vs G, AA vs GG, AA+GA vs GG, and AA vs GA+GG. In a stratified analysis by cancer type of CRC, there was an increased risk of sporadic CRC found in three genetic models: A vs G, AA vs GG, and AA+GA vs GG. In a stratified analysis by ethnicity, there was an increased CRC risk found among Asians in allele comparison genetic models, as well as Caucasians in two genetic models: AA+GA vs GG and A vs T. In summary, this meta-analysis demonstrates that rs9344 G>A polymorphism may be a risk factor for CRC.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S116258