Peripheral quantitative computed tomography-derived muscle density and peripheral magnetic resonance imaging-derived muscle adiposity: precision and associations with fragility fractures in women

To determine the degree to which muscle density and fractures are explained by inter and intramuscular fat (IMF). Women ⋝50 years of age (Hamilton, ON, Canada) had peripheral magnetic resonance imaging and peripheral quantitative computed tomography scans at 66% of the tibial length. Muscle on compu...

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Bibliographic Details
Published in:Journal of musculoskeletal & neuronal interactions 2014-12, Vol.14 (4), p.401-410
Main Authors: Wong, A K O, Beattie, K A, Min, K K H, Gordon, C, Pickard, L, Papaioannou, A, Adachi, J D
Format: Article
Language:English
Subjects:
Adiposity
Aged
Algorithms
Area Under Curve
Female
Fractures, Bone
Humans
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Middle Aged
Muscles - anatomy & histology
Odds Ratio
ROC Curve
Tomography, X-Ray Computed - methods
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Summary:To determine the degree to which muscle density and fractures are explained by inter and intramuscular fat (IMF). Women ⋝50 years of age (Hamilton, ON, Canada) had peripheral magnetic resonance imaging and peripheral quantitative computed tomography scans at 66% of the tibial length. Muscle on computed tomography images was segmented from subcutaneous fat and bone using fixed thresholds, computing muscle density. IMF was segmented from muscle within magnetic resonance images using a region-growing algorithm, computing IMF volume. Fracture history over the last 14 years was obtained. Odds ratios for fractures were determined for muscle density, adjusting for IMF volume, total hip BMD, age and body mass index. Women with a history of fractures were older (N=32, age:75.6±8.3 years) than those without (N=39, age: 67.0±5.2 years) (
ISSN:1108-7161