Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

• Published in: BMC veterinary research 2016-11, Vol.12 (1), p.243-243, Article 243
• Main Authors: Xie, Chunyan, Wu, Xin, Long, Cimin, Wang, Qinhua, Fan, Zhiyong, Li, Siming, Yin, Yulong
• Format: Article
• Language: English
• Subjects: Amino Acids - metabolism; Animal Feed; Animals; Antioxidants; Antioxidants - metabolism; Biological Transport, Active - drug effects; Chitosan - pharmacology; Dietary Supplements; Female; Food and nutrition; Health aspects; Nutritional aspects; Oligosaccharides; Oxidative stress; Placenta - drug effects; Placenta - enzymology; Placenta - metabolism; Pregnancy; Pregnancy Proteins - isolation & purification; Sows; Swine
• ISSN: 1746-6148; 1746-6148
• DOI: 10.1186/s12917-016-0872-8

Chitosan oligosaccharide (COS) is widely consumed as a functional food due to its multiple health effects, but few studies about COS supplement on placental antioxidant and nutrition transport capacity were reported. Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS supplementation during late gestation on placental amino acids transport and antioxidant defense capacity of sows. From day (d) 85 of gestation to parturition, sixteen pregnant sows were divided into a control group (basal diet without COS supplementation) and a COS group (30 mg COS/kg basal diet). Plasma sample of sow was collected on d 110 of gestation, and placenta tissue was obtained during parturition. Then plasma antioxidant enzyme's activities, the relative level of oxidant stress related genes, amino acids transport related genes and mTOR pathway molecules in placenta were determined. Results showed that maternal dietary supplementation with COS increased (P