Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows

Chitosan oligosaccharide (COS) is widely consumed as a functional food due to its multiple health effects, but few studies about COS supplement on placental antioxidant and nutrition transport capacity were reported. Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS s...

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Published in:BMC veterinary research 2016-11, Vol.12 (1), p.243-243, Article 243
Main Authors: Xie, Chunyan, Wu, Xin, Long, Cimin, Wang, Qinhua, Fan, Zhiyong, Li, Siming, Yin, Yulong
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Animal Feed
Animals
Antioxidants
Antioxidants - metabolism
Biological Transport, Active - drug effects
Chitosan - pharmacology
Dietary Supplements
Female
Food and nutrition
Health aspects
Nutritional aspects
Oligosaccharides
Oxidative stress
Placenta - drug effects
Placenta - enzymology
Placenta - metabolism
Pregnancy
Pregnancy Proteins - isolation & purification
Sows
Swine
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cited_by cdi_FETCH-LOGICAL-c560t-a6868dcb44652d61108237305e9c0f01a5fe19cd6fa888a8c9f0073b062bf88b3
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creator Xie, Chunyan
Wu, Xin
Long, Cimin
Wang, Qinhua
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Li, Siming
Yin, Yulong
description Chitosan oligosaccharide (COS) is widely consumed as a functional food due to its multiple health effects, but few studies about COS supplement on placental antioxidant and nutrition transport capacity were reported. Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS supplementation during late gestation on placental amino acids transport and antioxidant defense capacity of sows. From day (d) 85 of gestation to parturition, sixteen pregnant sows were divided into a control group (basal diet without COS supplementation) and a COS group (30 mg COS/kg basal diet). Plasma sample of sow was collected on d 110 of gestation, and placenta tissue was obtained during parturition. Then plasma antioxidant enzyme's activities, the relative level of oxidant stress related genes, amino acids transport related genes and mTOR pathway molecules in placenta were determined. Results showed that maternal dietary supplementation with COS increased (P 
doi_str_mv 10.1186/s12917-016-0872-8
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Taken pregnant sow as a model, we aimed to investigate the effects of dietary COS supplementation during late gestation on placental amino acids transport and antioxidant defense capacity of sows. From day (d) 85 of gestation to parturition, sixteen pregnant sows were divided into a control group (basal diet without COS supplementation) and a COS group (30 mg COS/kg basal diet). Plasma sample of sow was collected on d 110 of gestation, and placenta tissue was obtained during parturition. Then plasma antioxidant enzyme's activities, the relative level of oxidant stress related genes, amino acids transport related genes and mTOR pathway molecules in placenta were determined. Results showed that maternal dietary supplementation with COS increased (P &lt; 0.05) plasma total SOD, caused a downtrend in plasma MDA (0.05 &lt; P &lt; 0.10) on d 110 of gestation. Interestingly, the mRNA expression of some antioxidant genes in the placenta were increased (P &lt; 0.05) and pro-inflammatory cytokines were reduced (P &lt; 0.05) by COS supplement, whereas no significant difference was observed in the activities of placental total SOD and CAT between two groups. Additionally, further study demonstrated that COS feeding stimulated mTOR signaling pathway, increased amino acids transporters expression in placenta. 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subjects Amino Acids - metabolism
Animal Feed
Animals
Antioxidants
Antioxidants - metabolism
Biological Transport, Active - drug effects
Chitosan - pharmacology
Dietary Supplements
Female
Food and nutrition
Health aspects
Nutritional aspects
Oligosaccharides
Oxidative stress
Placenta - drug effects
Placenta - enzymology
Placenta - metabolism
Pregnancy
Pregnancy Proteins - isolation & purification
Sows
Swine
title Chitosan oligosaccharide affects antioxidant defense capacity and placental amino acids transport of sows
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