Population-based Estimate of the Prevalence of HER-2 Positive Breast Cancer Tumors for Early Stage Patients in the US

• Published in: Cancer investigation 2010-11, Vol.28 (9), p.963-968
• Main Authors: Cronin, Kathleen A., Harlan, Linda C., Dodd, Kevin W., Abrams, Jeffrey S., Ballard-Barbash, Rachel
• Format: Article
• Language: English
• Subjects: Asian - statistics & numerical data; Black or African American - statistics & numerical data; Breast carcinoma; Breast Neoplasms - epidemiology; Breast Neoplasms - ethnology; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Female; HER-2/neu; Hispanic or Latino - statistics & numerical data; Humans; Middle Aged; Multivariate Analysis; Neoplasm Staging; Population Surveillance - methods; Population-based study; Prevalence; Receptor, ErbB-2 - metabolism; SEER program; SEER Program - statistics & numerical data; United States - epidemiology; White People - statistics & numerical data
• ISSN: 0735-7907; 1532-4192; 1532-4192
• DOI: 10.3109/07357907.2010.496759

ABSTRACT The goal of this study was to estimate prevalence of HER-2 positive tumors in a population-based sample of 1026 women diagnosed in 2005 with early stage breast cancer. We modeled the relationship between patient and tumor characteristics and HER-2. HER-2 positive estimates were 19% for women aged ≤49 years and 15% aged ≥50 years. HER-2 varied by tumor grade and size in women aged ≤49 years but was not significant in multivariate analysis. Tumor grade and race were associated with HER-2 for women aged ≥50 years after controlling for other variables. HER-2 varies by age and by race and tumor in older women.