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The effect of proton pump inhibitors on fracture risk: report from the Canadian Multicenter Osteoporosis Study

Summary A large Canadian cohort was studied over 10 years to see if proton pump inhibitor (PPI) use increased the risk of sustaining a fragility fracture. We found an increased risk of fracture in individuals who used PPIs. The risk remained after controlling for other known fracture risk factors. I...

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Bibliographic Details
Published in:Osteoporosis international 2013-04, Vol.24 (4), p.1161-1168
Main Authors: Fraser, L-A., Leslie, W. D., Targownik, L. E., Papaioannou, A., Adachi, J. D.
Format: Article
Language:English
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Summary:Summary A large Canadian cohort was studied over 10 years to see if proton pump inhibitor (PPI) use increased the risk of sustaining a fragility fracture. We found an increased risk of fracture in individuals who used PPIs. The risk remained after controlling for other known fracture risk factors. Introduction Multiple retrospective studies have linked proton pump inhibitor use with increased risk of fragility fracture. We prospectively studied the association between PPI use and fracture in a large cohort over a 10-year period while controlling for known fracture risk factors. Methods We studied 9,423 participants in the Canadian Multicenter Osteoporosis Study. The cohort was formed in 1995–1997 and followed for 10 years with monitoring for incident nontraumatic fracture and PPI use. Cox regression analyses were used to assess the association between PPI use and incident fracture risk. Results PPI use, coded as a time-dependent variable, was associated with a shorter time to first nontraumatic fracture, hazard ratio (HR) = 1.75 (95 % confidence interval (CI) 1.41–2.17, p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-012-2112-9