Biomimetic approaches with smart interfaces for bone regeneration

A 'smart tissue interface' is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental in dictating the interface functionality. This review aims to investigate the...

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Published in:Journal of biomedical science 2016-11, Vol.23 (1), p.77-77, Article 77
Main Authors: Sailaja, G S, Ramesh, P, Vellappally, Sajith, Anil, Sukumaran, Varma, H K
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - metabolism
Biomedical research
Biomimetics
Bone and Bones - physiology
Bone Regeneration
Calcification, Physiologic
Extracellular Matrix - metabolism
Humans
Osseointegration
Review
Tissue Engineering
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cited_by cdi_FETCH-LOGICAL-c497t-913c453a0b0bda9fb216592a8e4431af34bfedbba1e3505280934d15a5f09363
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creator Sailaja, G S
Ramesh, P
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Varma, H K
description A 'smart tissue interface' is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental in dictating the interface functionality. This review aims to investigate the fundamental and favourable requirements of a 'smart tissue interface' that can positively influence the degree of healing and promote bone tissue regeneration. A biomaterial surface when interacts synergistically with the dynamic extracellular matrix, the healing process become accelerated through development of a smart interface. The interface functionality relies equally on bound functional groups and conjugated molecules belonging to the biomaterial and the biological milieu it interacts with. The essential conditions for such a special biomimetic environment are discussed. We highlight the impending prospects of smart interfaces and trying to relate the design approaches as well as critical factors that determine species-specific functionality with special reference to bone tissue regeneration.
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subjects Animals
Biocompatible Materials - metabolism
Biomedical research
Biomimetics
Bone and Bones - physiology
Bone Regeneration
Calcification, Physiologic
Extracellular Matrix - metabolism
Humans
Osseointegration
Review
Tissue Engineering
title Biomimetic approaches with smart interfaces for bone regeneration
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