PEPlife: A Repository of the Half-life of Peptides

Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of labile aminos acids, etc. In order to study this...

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Bibliographic Details
Published in:Scientific reports 2016-11, Vol.6 (1), p.36617-36617, Article 36617
Main Authors: Mathur, Deepika, Prakash, Satya, Anand, Priya, Kaur, Harpreet, Agrawal, Piyush, Mehta, Ayesha, Kumar, Rajesh, Singh, Sandeep, Raghava, Gajendra P. S.
Format: Article
Language:English
Subjects:
631/114/129/2044
631/114/2398
639/638/92/2783
Amino acid substitution
Amino acids
Browsing
Humanities and Social Sciences
multidisciplinary
Peptides
Science
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Summary:Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of labile aminos acids, etc. In order to study this scattered data, there is a pressing need for a repository dedicated to the half-life of peptides. To fill this lacuna, we have developed PEPlife ( http://crdd.osdd.net/raghava/peplife ), a manually curated resource of experimentally determined half-life of peptides. PEPlife contains 2229 entries covering 1193 unique peptides. Each entry provides detailed information of the peptide, like its name, sequence, half-life, modifications, the experimental assay for determining half-life, biological nature and activity of the peptide. We also maintain SMILES and structures of peptides. We have incorporated web-based modules to offer user-friendly data searching and browsing in the database. PEPlife integrates numerous tools to perform various types of analysis such as BLAST, Smith-Waterman algorithm, GGSEARCH, Jalview and MUSTANG. PEPlife would augment the understanding of different factors that affect the half-life of peptides like modifications, sequence, length, route of delivery of the peptide, etc. We anticipate that PEPlife will be useful for the researchers working in the area of peptide-based therapeutics.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep36617