Development of a tree shrew metabolic syndrome model and use of umbilical cord mesenchymal stem cell transplantation for treatment

The aim of this study was to establish a tree shrew metabolic syndrome model and demonstrate the utility of MSCs in treating metabolic syndrome. We used tree shrew umbilical cord mesenchymal stem cell (TS-UC-MSC) transplantation for the treatment of metabolic syndrome to demonstrate the clinical app...

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Bibliographic Details
Published in:Cytotechnology (Dordrecht) 2016-12, Vol.68 (6), p.2449-2467
Main Authors: Pan, Xing-hua, Zhu, Lu, Yao, Xiang, Liu, Ju-fen, Li, Zi-an, Yang, Jian-yong, Pang, Rong-qing, Ruan, Guang-ping
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Atherosclerosis
Biochemistry
Biomedicine
Biotechnology
Blood glucose
Blood pressure
Calories
Cardiovascular disease
Cell growth
Chemistry
Chemistry and Materials Science
Cytokines
Degeneration
Diabetes
Diet
Hepatocytes
Hyperglycemia
Hypertension
Immunology
Inflammation
Insulin resistance
Insulin secretion
Lipid metabolism
Lipids
Liver
Mesenchymal stem cells
Metabolic disorders
Metabolic syndrome
Metabolism
Necrosis
Original
Original Article
Penicillin
Stem cell transplantation
Stem cells
Umbilical cord
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Summary:The aim of this study was to establish a tree shrew metabolic syndrome model and demonstrate the utility of MSCs in treating metabolic syndrome. We used tree shrew umbilical cord mesenchymal stem cell (TS-UC-MSC) transplantation for the treatment of metabolic syndrome to demonstrate the clinical application of these stem cells and to provide a theoretical basis and reference methods for this treatment. Tree shrew metabolic syndrome model showed significant insulin resistance, high blood sugar, lipid metabolism disorders, and hypertension, consistent with the diagnostic criteria. TS-UC-MSC transplantation at 16 weeks significantly reduced blood sugar and lipid levels, improved insulin resistance and the regulation of insulin secretion, and reduced the expression levels of the pro-inflammatory cytokines IL-1 and IL-6 ( P  
ISSN:0920-9069
1573-0778
DOI:10.1007/s10616-016-9966-1