Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity

Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release diffe...

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Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-9
Main Authors: Raica, Marius, Rusu, Laura Cristina, Stratul, Stefan-Ioan, Jitariu, Adriana, Ceausu, Raluca A., Gaje, Pusa Nela, Popovici, Ramona Amina
Format: Article
Language:English
Subjects:
Allergies
Angiogenesis
Animals
Colleges & universities
Cytoplasm
Dentistry
Development and progression
Growth factors
Histamine
Humans
Immune system
Inflammation
Inflammation - pathology
Localization
Mast Cells - pathology
Medicine
Metastasis
Microscopy
Morphology
Mouth - pathology
Mouth Neoplasms - pathology
Neoplasms, Squamous Cell - pathology
Pharmacy
Pneumoviridae
Proteases
Review
Squamous cell carcinoma
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumors
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Summary:Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release different proinflammatory cytokines, tumor necrosis factor alpha (TNF-α), that promote leukocyte infiltration in various inflammatory states of the oral cavity. These cells play a key role in the inflammatory process and, as a consequence, their number changes in different pathologic conditions of the oral cavity, like gingivitis, periodontitis, and so on. MCs also represent a rich source of proteases, especially of mast cell tryptase and chymase, which directly degrade the extracellular matrix through their proteolytic activity and thus indirectly stimulate angiogenesis and facilitate invasion and metastasis. It may be stated that mast cells could have an impact on primary tumor development, progression, and metastases in oral squamous cell carcinoma. By understanding the role of mast cells in the pathogenesis of different inflammatory and tumor diseases of the oral cavity, these cells may become therapeutic targets that could possibly improve the prognosis and survival of these patients.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/9235080