p62 in Cancer: Signaling Adaptor Beyond Autophagy

Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2016-10, Vol.167 (3), p.606-609
Main Authors: Moscat, Jorge, Karin, Michael, Diaz-Meco, Maria T.
Format: Article
Language:English
Subjects:
Autophagy
Carcinogenesis - metabolism
Carcinogenesis - pathology
Epithelial Cells - metabolism
Epithelial Cells - pathology
Humans
Neoplasms - metabolism
Neoplasms - pathology
Sequestosome-1 Protein - metabolism
Signal Transduction
Stress, Physiological
Tumor Microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma. New evidence supports an autophagy-independent key role of the adaptor p62 in cancer.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2016.09.030