Rational Design of Materials Interface for Efficient Capture of Circulating Tumor Cells

Originating from primary tumors and penetrating into blood circulation, circulating tumor cells (CTCs) play a vital role in understanding the biology of metastasis and have great potential for early cancer diagnosis, prognosis and personalized therapy. By exploiting the specific biophysical and bioc...

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Bibliographic Details
Published in:Advanced science 2015-11, Vol.2 (11), p.1500118-n/a
Main Authors: Li, Yong‐Qiang, Chandran, Bevita K., Lim, Chwee Teck, Chen, Xiaodong
Format: Article
Language:English
Subjects:
Biomarkers
Blood
Cancer
cancer diagnosis
capture
Cell adhesion & migration
circulating tumor cells
Design
Immunology
material interface
Medical diagnosis
Medical prognosis
Metastasis
NMR
Nuclear magnetic resonance
Patients
Prostate
Review
Reviews
tumor metastasis
Tumors
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Summary:Originating from primary tumors and penetrating into blood circulation, circulating tumor cells (CTCs) play a vital role in understanding the biology of metastasis and have great potential for early cancer diagnosis, prognosis and personalized therapy. By exploiting the specific biophysical and biochemical properties of CTCs, various material interfaces have been developed for the capture and detection of CTCs from blood. However, due to the extremely low number of CTCs in peripheral blood, there exists a need to improve the efficiency and specificity of the CTC capture and detection. In this regard, a critical review of the numerous reports of advanced platforms for highly efficient and selective capture of CTCs, which have been spurred by recent advances in nanotechnology and microfabrication, is essential. This review gives an overview of unique biophysical and biochemical properties of CTCs, followed by a summary of the key material interfaces recently developed for improved CTC capture and detection, with focus on the use of microfluidics, nanostructured substrates, and miniaturized nuclear magnetic resonance‐based systems. Challenges and future perspectives in the design of material interfaces for capture and detection of CTCs in clinical applications are also discussed. Circulating tumor cells (CTCs) are promising biomarkers for the early diagnosis and prognosis of cancer. However, sensitive CTC detection is challenging due to the extremely low number of CTCs in the peripheral blood. This review summarizes recent representative works on the design of advanced material interfaces for efficient CTC capture and isolation, providing some insights into further CTC detection studies.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.201500118