Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function

Mutations that reduce somatotropic signaling result in improved lifespan and health-span in model organisms and humans. However, whether reduced circulating insulin-like growth factor-I (IGF-I) level is detrimental to cognitive and muscle function in older adults remains understudied. A cross-sectio...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2016-10, Vol.8 (10), p.2414-2424
Main Authors: Perice, Leland, Barzilai, Nir, Verghese, Joe, Weiss, Erica F, Holtzer, Roee, Cohen, Pinchas, Milman, Sofiya
Format: Article
Language:English
Subjects:
Aged, 80 and over
Cognition - physiology
Cross-Sectional Studies
Female
Gait - physiology
Hand Strength - physiology
Humans
Insulin-Like Growth Factor I - metabolism
Longevity - physiology
Male
Muscle, Skeletal - physiology
Neuropsychological Tests
Research Paper
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Summary:Mutations that reduce somatotropic signaling result in improved lifespan and health-span in model organisms and humans. However, whether reduced circulating insulin-like growth factor-I (IGF-I) level is detrimental to cognitive and muscle function in older adults remains understudied. A cross-sectional analysis was performed in Ashkenazi Jews with exceptional longevity (age ≥95 years). Cognition was assessed using the Mini-Mental State Examination and muscle function with the chair rise test, grip-strength, and gait speed. Muscle mass was estimated using the skeletal muscle index. Serum IGF-I was measured with liquid chromatography mass spectrometry. In gender stratified age-adjusted logistic regression analysis, females with IGF-I levels in the first tertile had lower odds of being cognitively impaired compared to females with IGF-I levels within the upper two tertiles, OR (95% CI) 0.39 (0.19-0.82). The result remained significant after adjustment for multiple parameters. No significant association was identified in males between IGF-I and cognition. No relationship was found between IGF-I tertiles and muscle function and muscle mass in females or males. Lower circulating IGF-I is associated with better cognitive function in females with exceptional longevity, with no detriment to skeletal muscle mass and function.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.101063