Disinfection of human skin allografts in tissue banking: a systematic review report

The use of skin allografts to temporarily replace lost or damaged skin is practiced worldwide. Naturally occurring contamination can be present on skin or can be introduced at recovery or during processing. This contamination can pose a threat to allograft recipients. Bacterial culture and disinfect...

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Bibliographic Details
Published in:Cell and tissue banking 2016-12, Vol.17 (4), p.585-592
Main Authors: Johnston, C., Callum, J., Mohr, J., Duong, A., Garibaldi, A., Simunovic, N., Ayeni, O. R.
Format: Article
Language:English
Subjects:
Allografts - microbiology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Culture Techniques - methods
Disinfection - methods
Full Length Review
Humans
Life Sciences
Skin - microbiology
Skin Transplantation - adverse effects
Skin Transplantation - methods
Sterilization - methods
Tissue Banks
Transplant Surgery
Transplantation, Homologous
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Summary:The use of skin allografts to temporarily replace lost or damaged skin is practiced worldwide. Naturally occurring contamination can be present on skin or can be introduced at recovery or during processing. This contamination can pose a threat to allograft recipients. Bacterial culture and disinfection of allografts are mandated, but the specific practices and methodologies are not dictated by standards. A systematic review of literature from three databases found 12 research articles that evaluated bioburden reduction processes of skin grafts. The use of broad spectrum antibiotics and antifungal agents was the most frequently identified disinfection method reported demonstrating reductions in contamination rates. It was determined that the greatest reduction in the skin allograft contamination rates utilized 0.1 % peracetic acid or 25 kGy of gamma irradiation at lower temperatures.
ISSN:1389-9333
1573-6814
DOI:10.1007/s10561-016-9569-2