Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indices associated with adverse events in post-operation gastric cancer patients receiving chemot...

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Bibliographic Details
Published in:BMC cancer 2016-11, Vol.16 (1), p.900-900, Article 900
Main Authors: Seo, Seung Hee, Kim, Sung-Eun, Kang, Yoon-Koo, Ryoo, Baek-Yeol, Ryu, Min-Hee, Jeong, Jae Ho, Kang, Shin Sook, Yang, Mihi, Lee, Jung Eun, Sung, Mi-Kyung
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Body Mass Index
Cancer
Cancer patients
Cancer therapies
Care and treatment
Chemotherapy
Complications and side effects
Constipation - etiology
Drug dosages
Drug-Related Side Effects and Adverse Reactions - diagnosis
Drug-Related Side Effects and Adverse Reactions - etiology
Febrile Neutropenia - etiology
Female
Gastrectomy - adverse effects
Gastrectomy - methods
Gastric cancer
Gastrointestinal surgery
Health aspects
Hematology
Humans
Hypoalbuminemia - complications
Logistic Models
Male
Malnutrition
Malnutrition - complications
Middle Aged
Multivariate Analysis
Nutrition
Nutrition Assessment
Nutritional Status
Parenteral nutrition
Patients
Postoperative Period
Preoperative Period
Retrospective Studies
Risk Factors
Sex Factors
Stomach cancer
Stomach Neoplasms - drug therapy
Stomach Neoplasms - surgery
Vomiting - etiology
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Summary:Malnutrition in gastrectomized patients receiving chemotherapy is associated with the susceptibility to chemotherapy-related adverse events. This study evaluated pre-operative nutritional status-related indices associated with adverse events in post-operation gastric cancer patients receiving chemotherapy. Medical records of 234 gastrectomized patients under adjuvant tegafur/gimeracil/oteracil chemotherapy with extended lymph node dissection were analyzed. Nutritional status assessment included Patient-Generated Subjective Global Assessment (PG-SGA), body weight, body mass index, serum albumin concentration, and Nutrition Risk Index (NRI). Chemotherapy-originated adverse events were determined using Common Terminology Criteria for Adverse Events. PG-SGA indicated 59% of the patients were malnourished, and 27.8% of the patients revealed serious malnutrition with PG-SGA score of ≥9. Fifteen % of patients lost ≥10% of the initial body weight, 14.5% of the patients had hypoalbuminemia (
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-016-2934-5