Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes

Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy ag...

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Published in:Scientific reports 2016-11, Vol.6 (1), p.37354-37354, Article 37354
Main Authors: de Gonzalo-Calvo, D., Kenneweg, F., Bang, C., Toro, R., van der Meer, R. W., Rijzewijk, L. J., Smit, J. W., Lamb, H. J., Llorente-Cortes, V., Thum, T.
Format: Article
Language:English
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Biomarkers
Cardiomyopathy
Diabetes
Diabetes mellitus
Heart
Heart diseases
Humanities and Social Sciences
Magnetic resonance imaging
multidisciplinary
Muscle contraction
Myocardial infarction
Non-coding RNA
Science
Science (multidisciplinary)
Smooth muscle
Transcription
Ultrasonic imaging
Ventricle
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Summary:Contractile dysfunction is underdiagnosed in early stages of diabetic cardiomyopathy. We evaluated the potential of circulating long non-coding RNAs (lncRNAs) as biomarkers of subclinical cardiac abnormalities in type 2 diabetes. Forty-eight men with well-controlled type 2 diabetes and 12 healthy age-matched volunteers were enrolled in the study. Left ventricular (LV) parameters were measured by magnetic resonance imaging. A panel of lncRNAs was quantified in serum by RT-qPCR. No differences in expression levels of lncRNAs were observed between type 2 diabetes patients and healthy volunteers. In patients with type 2 diabetes, long intergenic non-coding RNA predicting cardiac remodeling (LIPCAR) was inversely associated with diastolic function, measured as E/A peak flow (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep37354