Damage-associated molecular patterns in cancer: a double-edged sword

Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer, as well as in the host response to cytotoxic anti-tumor therapy....

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Bibliographic Details
Published in:Oncogene 2016-11, Vol.35 (46), p.5931-5941
Main Authors: Hernandez, C, Huebener, P, Schwabe, R F
Format: Article
Language:English
Subjects:
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631/67/580/1884
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Alarmins - genetics
Alarmins - metabolism
Animals
Apoptosis
Carcinogenesis
Cell Biology
Cell death
Cell Death - genetics
Cell Death - immunology
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - immunology
Cell Transformation, Neoplastic - metabolism
Cytotoxicity
Disease Progression
Gene expression
Genetic aspects
Genotypes
Health aspects
Human Genetics
Humans
Immune system
Immunogenicity
Immunomodulation - genetics
Inflammation
Inflammation - complications
Inflammation - genetics
Inflammation - immunology
Inflammation - metabolism
Internal Medicine
Medicine
Medicine & Public Health
Molecular biology
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Neoplasms - therapy
Oncology
review
Stress, Physiological - genetics
Stress, Physiological - immunology
Tumor cells
Tumorigenesis
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Summary:Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer, as well as in the host response to cytotoxic anti-tumor therapy. As such, DAMPs may exert protective functions by alerting the immune system to the presence of dying tumor cells, thereby triggering immunogenic tumor cell death. On the other hand, cell death and release of DAMPs may also trigger chronic inflammation and, thereby promote the development or progression of tumors. Here, we will review the contribution of candidate DAMPs and their receptors, and discuss the evidence for DAMPs as tumor-promoting and anti-tumor effectors, as well as unsolved questions such as DAMP release from non-tumor cells as well as the existence of tumor-specific DAMPs.
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2016.104