Integrin-mediated mechanotransduction

Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in a process called mechanotransduction. At these adhesion sites, integrins connect the extracellular matrix (ECM) with the F-actin cy...

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Bibliographic Details
Published in:The Journal of cell biology 2016-11, Vol.215 (4), p.445-456
Main Authors: Sun, Zhiqi, Guo, Shengzhen S, Fässler, Reinhard
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena
Biophysics
Cell Adhesion
Cell adhesion & migration
Cytoskeleton
Homeostasis
Humans
Integrins - metabolism
Mechanotransduction, Cellular
Neoplasms - metabolism
Neoplasms - pathology
Proteins
Reviews
Signal transduction
Talin - metabolism
Viscoelasticity
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Summary:Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in a process called mechanotransduction. At these adhesion sites, integrins connect the extracellular matrix (ECM) with the F-actin cytoskeleton and transduce mechanical forces generated by the actin retrograde flow and myosin II to the ECM through mechanosensitive focal adhesion proteins that are collectively termed the "molecular clutch." The transmission of forces across integrin-based adhesions establishes a mechanical reciprocity between the viscoelasticity of the ECM and the cellular tension. During mechanotransduction, force allosterically alters the functions of mechanosensitive proteins within adhesions to elicit biochemical signals that regulate both rapid responses in cellular mechanics and long-term changes in gene expression. Integrin-mediated mechanotransduction plays important roles in development and tissue homeostasis, and its dysregulation is often associated with diseases.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201609037