Elevated preoperative HMGB1 as predictor of myocardial injury post-percutaneous coronary intervention

In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention.We evaluated 302 consecutive patients who underwent percutaneous coronary intervention. They were divided into equal tertiles based on their preoperat...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2016-11, Vol.95 (46), p.e5149-e5149
Main Authors: Jin, Peng, Zhou, Qi, Song, Shujiang, Xu, Jinpeng, Zhang, Minli, Zhu, Ming, Kang, Meili, Shi, Xiangming, Shi, Junting, Lu, Di, Li, Jing
Format: Article
Language:English
Subjects:
Cardiomyopathies - blood
Cardiomyopathies - etiology
Female
HMGB1 Protein - blood
Humans
Male
Middle Aged
Observational Study
Percutaneous Coronary Intervention
Postoperative Complications - blood
Postoperative Complications - etiology
Predictive Value of Tests
Preoperative Period
Prospective Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, we evaluated the impact of preoperative high mobility group box 1 (HMGB1) on myocardial injury post-percutaneous coronary intervention.We evaluated 302 consecutive patients who underwent percutaneous coronary intervention. They were divided into equal tertiles based on their preoperative HMGB1 levels. Creatine kinase-MB and troponin I levels were measured at baseline, 8- and 24-hours after the procedure, while clinical outcomes were followed up for 1 year.The occurrence of post-procedural myocardial injury was significantly higher in the tertile comprising of patients with elevated HMGB1 levels. Moreover, these patients showed significantly higher post-procedural peak values of creatine kinase-MB and troponin I in comparison to patients with lower HMGB1 levels. Event-free survival was significantly associated with HMGB1 levels, with worst event-free survival in patients with elevated HMGB1 levels.Elevated preoperative HMGB1 was a predictor of myocardial injury after percutaneous coronary intervention, and was associated with the worst clinical outcomes during 1-year follow up.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000005149