LRRK2 contributes to monocyte dysregulation in Parkinson's disease

HC: Healthy control IFNγ: Interferon γ KO: Knock out LPS: Lipopolysaccharide LRRK2: Leucine-rich repeat kinase 2 NT: Non-transgenic OX: Overexpressing PBMCs: Peripheral blood mononuclear cells PD: Parkinson's disease RKU: Universitats- und Rehabilitationskliniken Ulm WT: Wild type

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Bibliographic Details
Published in:Acta neuropathologica communications 2016-11, Vol.4 (1), p.123-123, Article 123
Main Authors: Bliederhaeuser, Corinna, Zondler, Lisa, Grozdanov, Veselin, Ruf, Wolfgang P, Brenner, David, Melrose, Heather L, Bauer, Peter, Ludolph, Albert C, Gillardon, Frank, Kassubek, Jan, Weishaupt, Jochen H, Danzer, Karin M
Format: Article
Language:English
Subjects:
Aged
Animals
B-Lymphocytes - metabolism
GPI-Linked Proteins - metabolism
Humans
Letter to the Editor
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - deficiency
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism
Lipopolysaccharide Receptors - metabolism
Mice, Transgenic
Monocytes - metabolism
Parkinsonian Disorders - metabolism
Receptors, IgG - metabolism
Spleen - metabolism
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Summary:HC: Healthy control IFNγ: Interferon γ KO: Knock out LPS: Lipopolysaccharide LRRK2: Leucine-rich repeat kinase 2 NT: Non-transgenic OX: Overexpressing PBMCs: Peripheral blood mononuclear cells PD: Parkinson's disease RKU: Universitats- und Rehabilitationskliniken Ulm WT: Wild type
ISSN:2051-5960
2051-5960
DOI:10.1186/s40478-016-0396-2