Paroxetine Can Enhance Neurogenesis during Neurogenic Differentiation of Human Adipose-derived Stem Cells

Some antidepressant drugs can promote neuronal cell proliferation as well as hippocampal neurogenesis in human and animal models. Furthermore, adipose tissue is an available source of adult stem cells with the ability to differentiate in to multiple lineages. Therefore, human Adipose-Derived Stem Ce...

Full description

Saved in:
Bibliographic Details
Published in:Avicenna journal of medical biotechnology 2016-10, Vol.8 (4), p.152-158
Main Authors: Jahromi, Maliheh, Razavi, Shahnaz, Amirpour, Nushin, Khosravizadeh, Zahra
Format: Article
Language:English
Subjects:
Adipose tissue
Cell proliferation
Dosage and administration
Health aspects
Neurogenesis
Original
Paroxetine
Stem cells
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Some antidepressant drugs can promote neuronal cell proliferation as well as hippocampal neurogenesis in human and animal models. Furthermore, adipose tissue is an available source of adult stem cells with the ability to differentiate in to multiple lineages. Therefore, human Adipose-Derived Stem Cells (hAD-SCs) may be a suitable source for regenerative medical applications. Since there is no evidence for the effect of Paroxetine as the most commonly prescribed antidepressant drug for neurogenic potential of hADSCs, an attempt was made to determine the effect of Paroxetine on proliferation and neural differentiation of hADSCs. ADSCs were isolated from human abdominal fat. These cells differentiated to neuron-like cells and were treated with Paroxetine. 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide (MTT) assay and immunofluorescence technique were used for assessment of cell proliferation and neurogenic differentiation potential of induced cells, respectively. MTT assay analysis showed that Paroxetine significantly increased the proliferation rate of induced hADSCs (p
ISSN:2008-2835
2008-4625