The presence of 3-hydroxy oxylipins in pathogenic microbes

► This paper reviews the available literature on microbial 3-hydroxy oxylipins. ► These molecules are reported to mediate cellular pathology and physiology. ► Biosynthetic pathways of these molecules could serve as targets for developing drugs. There is a sufficient body of work documenting the dist...

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Bibliographic Details
Published in:Prostaglandins & other lipid mediators 2012-01, Vol.97 (1), p.17-21
Main Authors: Sebolai, Olihile M., Pohl, Carolina H., Kock, Lodewyk J.F., Chaturvedi, Vishnu, del Poeta, Maurizio
Format: Article
Language:English
Subjects:
3-Hydroxy oxylipins
Animals
Bacteria
Bacteria - metabolism
Bacteria - pathogenicity
Humans
Inflammation
Oxylipins - metabolism
Pathogenesis
Yeast
Yeasts - metabolism
Yeasts - pathogenicity
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Summary:► This paper reviews the available literature on microbial 3-hydroxy oxylipins. ► These molecules are reported to mediate cellular pathology and physiology. ► Biosynthetic pathways of these molecules could serve as targets for developing drugs. There is a sufficient body of work documenting the distribution of 3-hydroxy oxylipins in microbes. However, there is limited information on the role of these compounds in microbial pathogenesis. When derived from mammalian cells, these compounds regulate patho-biological processes, thus an understanding of 3-hydroxy oxylipin function and metabolism could prove important in shedding light on how these compounds mediate cellular pathology and physiology. This could present 3-hydroxy oxylipin biosynthetic pathways as targets for drug development. In this minireview, we interrogate the relevant yeast and bacterial 3-hydroxy oxylipin literature in order to appreciate how these compounds may influence the inflammatory response leading to disease development.
ISSN:1098-8823
DOI:10.1016/j.prostaglandins.2011.11.001