The role of miRNAs in cardiovascular disease risk factors

Abstract Coronary artery disease and atherosclerosis are complex pathologies that develop over time due to genetic and environmental factors. Differential expression of miRNAs has been identified in patients with coronary artery disease and atherosclerosis, however, their association with cardiovasc...

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Bibliographic Details
Published in:Atherosclerosis 2016-11, Vol.254, p.271-281
Main Authors: Jones Buie, Joy N, Goodwin, Andrew J, Cook, James A, Halushka, Perry V, Fan, Hongkuan
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - genetics
Cell Communication
Cholesterol - blood
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
Homeostasis
Humans
Hyperlipidemias - complications
Hypertension - complications
Lipoproteins, HDL - metabolism
Lipoproteins, LDL - metabolism
Mice
MicroRNAs - genetics
miRNA
Nicotiana
Obesity - complications
Review
Risk Factors
Smoking - adverse effects
Treatment Outcome
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Summary:Abstract Coronary artery disease and atherosclerosis are complex pathologies that develop over time due to genetic and environmental factors. Differential expression of miRNAs has been identified in patients with coronary artery disease and atherosclerosis, however, their association with cardiovascular disease risk factors, including hyperlipidemia, hypertension, obesity, diabetes, lack of physical activity and smoking, remains unclear. This review examines the role of miRNAs as either biomarkers or potential contributors to the pathophysiology of these aforementioned risk factors. It is intended to provide an overview of the published literature which describes alterations in miRNA levels in both human and animal studies of cardiovascular risk factors and when known, the possible mechanism by which these miRNAs may exert either beneficial or deleterious effects. The intent of this review is engage clinical, translational, and basic scientists to design future collaborative studies to further elucidate the potential role of miRNAs in cardiovascular diseases.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2016.09.067