Arrangement at the nanoscale: Effect on magnetic particle hyperthermia

In this work, we present the arrangement of Fe 3 O 4 magnetic nanoparticles into 3D linear chains and its effect on magnetic particle hyperthermia efficiency. The alignment has been performed under a 40 mT magnetic field in an agarose gel matrix. Two different sizes of magnetite nanoparticles, 10 an...

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Bibliographic Details
Published in:Scientific reports 2016-11, Vol.6 (1), p.37934-37934, Article 37934
Main Authors: Myrovali, E., Maniotis, N., Makridis, A., Terzopoulou, A., Ntomprougkidis, V., Simeonidis, K., Sakellari, D., Kalogirou, O., Samaras, T., Salikhov, R., Spasova, M., Farle, M., Wiedwald, U., Angelakeris, M.
Format: Article
Language:English
Subjects:
639/925/357/997
639/925/930/12
Anisotropy
Diffusion models
Efficiency
Electron microscopy
Fever
Humanities and Social Sciences
Hyperthermia
Magnetic fields
Magnetite
multidisciplinary
Nanoparticles
Scanning electron microscopy
Science
Temperature effects
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Summary:In this work, we present the arrangement of Fe 3 O 4 magnetic nanoparticles into 3D linear chains and its effect on magnetic particle hyperthermia efficiency. The alignment has been performed under a 40 mT magnetic field in an agarose gel matrix. Two different sizes of magnetite nanoparticles, 10 and 40 nm, have been examined, exhibiting room temperature superparamagnetic and ferromagnetic behavior, in terms of DC magnetic field, respectively. The chain formation is experimentally visualized by scanning electron microscopy images. A molecular Dynamics anisotropic diffusion model that outlines the role of intrinsic particle properties and inter-particle distances on dipolar interactions has been used to simulate the chain formation process. The anisotropic character of the aligned samples is also reflected to ferromagnetic resonance and static magnetometry measurements. Compared to the non-aligned samples, magnetically aligned ones present enhanced heating efficiency increasing specific loss power value by a factor of two. Dipolar interactions are responsible for the chain formation of controllable density and thickness inducing shape anisotropy, which in turn enhances magnetic particle hyperthermia efficiency.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep37934