A prospective observational study of early intervention with erythropoietin therapy and renal survival in non-dialysis chronic kidney disease patients with anemia: JET-STREAM Study

Background There is limited data showing that early treatment for anemia could prolong renal survival in non-dialysis chronic kidney disease (CKD) patients. We therefore investigated the relationship between hemoglobin (Hb) levels at initiation of epoetin beta therapy and renal outcome in non-dialys...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2016-12, Vol.20 (6), p.885-895
Main Authors: Akizawa, Tadao, Tsubakihara, Yoshiharu, Hirakata, Hideki, Watanabe, Yuzo, Hase, Hiroki, Nishi, Shinichi, Babazono, Tetsuya, Kumagai, Michiko, Katakura, Shingo, Uemura, Yukari, Ohashi, Yasuo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anemia - drug therapy
Erythropoietin - therapeutic use
Female
Hematinics - therapeutic use
Hemoglobins - analysis
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Original
Original Article
Proportional Hazards Models
Prospective Studies
Renal Insufficiency, Chronic - complications
Urology
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Summary:Background There is limited data showing that early treatment for anemia could prolong renal survival in non-dialysis chronic kidney disease (CKD) patients. We therefore investigated the relationship between hemoglobin (Hb) levels at initiation of epoetin beta therapy and renal outcome in non-dialysis CKD patients with anemia. Methods In this prospective, multi-center, observational study, non-dialysis CKD patients with anemia who were naïve to erythropoiesis-stimulating agents (ESAs) were divided into three groups based on their Hb levels at initiation of epoetin beta therapy (Group I: 10 ≤ Hb 
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-015-1225-9