Alkynyl-Containing Peptides of Marine Origin: A Review

Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In f...

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Bibliographic Details
Published in:Marine drugs 2016-11, Vol.14 (11), p.216
Main Authors: Chai, Qiu-Ye, Yang, Zhen, Lin, Hou-Wen, Han, Bing-Nan
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Alkynes - pharmacology
Aquatic Organisms - chemistry
Biological Products - chemistry
Biological Products - pharmacology
Cyanobacteria - chemistry
Humans
Peptide Synthases - metabolism
Peptides - chemistry
Peptides - pharmacology
Polyketide Synthases - metabolism
Review
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Summary:Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In fact, more than 90% of these peptides described in the literature are of cyanobacterial origin. Interestingly, all the linear peptides featured with terminal alkyne were solely discovered from marine cyanobacteria. The objective of this article is to provide an overview on the types, structural characterization of these unusual terminal alkynyl fatty acyl units, as well as the sources and biological functions of their composed peptides. Many of these peptides have a variety of biological activities, including antitumor, antibacterial, antimalarial, etc. Further, we have also discussed the evident biosynthetic origin responsible for formation of terminal alkynes of natural PKS (polyketide synthase)/NRPS (nonribosome peptide synthetase) hybrids.
ISSN:1660-3397
1660-3397
DOI:10.3390/md14110216