Clinical factors associated with initiation of and persistence with ADP receptor-inhibiting oral antiplatelet treatment after acute coronary syndrome: a nationwide cohort study from Finland

ObjectivesTo study patient selection for and persistence with ADP receptor-inhibiting oral antiplatelet (OAP) treatment after acute coronary syndrome (ACS).DesignObservational, retrospective, cohort study linking real-life patient-level register data.SettingNationwide drug usage study using data of...

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Bibliographic Details
Published in:BMJ open 2016-11, Vol.6 (11), p.e012604-e012604
Main Authors: Prami, Tuire, Khanfir, Houssem, Deleskog, Anna, Hasvold, Pål, Kytö, Ville, Reissell, Eeva, Airaksinen, Juhani
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - drug therapy
Acute coronary syndromes
Age
Aged
Aged, 80 and over
Angina pectoris
Angina Pectoris - drug therapy
Cardiovascular Medicine
Chronic illnesses
Comorbidity
Compliance
Disease prevention
Drug dosages
Drug therapy
Female
Finland
Heart attacks
Hospitalization
Humans
Institutionalization
Male
Medication Adherence - statistics & numerical data
Middle Aged
Mortality
Myocardial Infarction - drug therapy
Patient Selection
Patients
Platelet Aggregation Inhibitors - therapeutic use
Population
Prescription drugs
Purinergic P2Y Receptor Antagonists - therapeutic use
Retrospective Studies
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Summary:ObjectivesTo study patient selection for and persistence with ADP receptor-inhibiting oral antiplatelet (OAP) treatment after acute coronary syndrome (ACS).DesignObservational, retrospective, cohort study linking real-life patient-level register data.SettingNationwide drug usage study using data of patients with ACS discharged from hospitals in Finland.ParticipantsThe study population consisted of 54 416 patients (aged ≥18 years) following hospital admission for unstable angina pectoris or myocardial infarction during 2009–2013. Patients were classified as either OAP or non-OAP users based on drug purchases within 7 days of discharge.Outcome measuresInitiation of and a 12-month persistence with OAP medication.ResultsIn total, 49% of patients with ACS received OAP treatment after hospital discharge. Women represented 40% of the population, but only 32% of them became OAP users (adjusted OR for initiation compared with men 0.8; p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2016-012604