Successful improvement of Buschke-Löwenstein tumour in an HIV-infected patient with antiretroviral therapy alone

Buschke-Löwenstein tumour (BLT), also defined as giant condyloma acuminatum, is a rare exophytic tumour affecting the anogenital and perianal regions associated with human papillomavirus (HPV) infections, with a potential of malignant transformation and which is at a greater risk in T-cell mediated...

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Bibliographic Details
Published in:BMJ case reports 2016-11, Vol.2016, p.bcr2016217753
Main Authors: Grodner, Camille, Henn, Aurélia, Lelièvre, Jean-Daniel, Gallien, Sébastien
Format: Article
Language:English
Subjects:
Anti-Retroviral Agents - therapeutic use
Black
Buschke-Lowenstein Tumor - drug therapy
Buschke-Lowenstein Tumor - pathology
Cytokines
Drug therapy
Europe (West)
HIV
HIV Infections - complications
HIV Infections - drug therapy
Human immunodeficiency virus
Human papillomavirus
Humans
Immune system
Infections
Male
Middle Aged
Papillomaviridae
Patients
Pelvic Neoplasms - drug therapy
Pelvic Neoplasms - pathology
Tuberculosis
Tumors
Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions
Warts
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Summary:Buschke-Löwenstein tumour (BLT), also defined as giant condyloma acuminatum, is a rare exophytic tumour affecting the anogenital and perianal regions associated with human papillomavirus (HPV) infections, with a potential of malignant transformation and which is at a greater risk in T-cell mediated immunodeficient patients. Different therapeutic options, alone or in combination, have been reported for the treatment of BLT including local therapy but wide surgical local excision is however recommended as the most important therapeutic intervention. We report a case of a HIV-infected man who developed a voluminous pelvic BLT which disappeared progressively under antiretroviral therapy with no additional treatment, contemporary to an improvement of his immunity, highlighting the possible spontaneous reversibility of HPV-induced tumours in treated HIV infection.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2016-217753