Clinicopathological significance of lymphangiogenesis detected by immunohistochemistry using D2-40 monoclonal antibody in breast cancer

To elucidate the association between the lymphangiogenesis and clinicopathological factors including the survival in breast cancer, 91 Japanese patients with breast cancer were investigated.　The lymphangiogenesis was evaluated by the count of lymph vessel density (LVD) with immunohistochemical metho...

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Bibliographic Details
Published in:FUKUSHIMA JOURNAL OF MEDICAL SCIENCE 2016, Vol.62(1), pp.57-63
Main Authors: Abe, Noriko, Ohtake, Tohru, Saito, Katsuharu, Kumamoto, Kensuke, Sugino, Takashi, Takenoshita, Seiichi
Format: Article
Language:English
Subjects:
Breast cancer
D2-40
Immunohistochemistry
LVD
Lymphangiogenesis
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Summary:To elucidate the association between the lymphangiogenesis and clinicopathological factors including the survival in breast cancer, 91 Japanese patients with breast cancer were investigated.　The lymphangiogenesis was evaluated by the count of lymph vessel density (LVD) with immunohistochemical method using D2-40 monoclonal antibody, a specific marker for lymphatic endothelial cells. D2-40-positive lymph vessels were detected in 87 of 91 cases, and were mainly distributed in the peritumoral lesions or around the tumor edge.　There was a significant difference in disease-free survival (DFS) and overall survival (OS) between patients with high LVD and with low LVD (p=0.02, 0.01, respectively, log-rank test).　In addition, LVD significantly correlated with the following clinicopathological factors: menopausal status (p
ISSN:0016-2590
2185-4610
DOI:10.5387/fms.2015-10