Expression IRF/MUM1>25% Predictor to Three-year Survival of Diffuse Large B Cell Lymphoma in the Immunochemotherapy Era

Non Hodgkin lymphoma-Diffuse large B cell lymphoma (DLBC) is composed of more varieties of one disease. Analysis and understanding of a wide range of characteristics of the disease, which include: clinical, immunohistochemical, cytogenetic and molecular characteristics may improve treatment results....

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Bibliographic Details
Published in:Medicinski arhiv 2016-10, Vol.70 (5), p.342-347
Main Authors: Sofo-Hafizovic, Alma, Chikha, Adisa, Gojak, Refet, Hadzimesic, Emina Suljovic
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Female
Humans
Immunotherapy
Interferon Regulatory Factors - metabolism
Lymphoma, Large B-Cell, Diffuse - drug therapy
Lymphoma, Large B-Cell, Diffuse - metabolism
Lymphoma, Large B-Cell, Diffuse - mortality
Male
Middle Aged
Original Paper
Prospective Studies
Retrospective Studies
Survival Rate
Treatment Outcome
Young Adult
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Summary:Non Hodgkin lymphoma-Diffuse large B cell lymphoma (DLBC) is composed of more varieties of one disease. Analysis and understanding of a wide range of characteristics of the disease, which include: clinical, immunohistochemical, cytogenetic and molecular characteristics may improve treatment results. achieving the estimated three-year survival and influence of IRF/MUM1 expression to three-year survival. A study was retrospective-prospective, patients were followed for seven years a period of dine. The study included 60 patients de novo DLBCL. Age was 18-72 years old, the average age 45 years, male 31 (51,7%) and female 29 (48.3%). Median follow-up was 47 months (3-91 months). To determine differentiation immunophenotype antibodies those were used anti-CD20, anti-CD10, anti-Bcl-6, IRF-4/MUM1, CD 138. Included the GCB type was 65%. Impact prognostic index IPI>2 GBC vs non GBC p=0,038 X . Statistically significant difference was confirmed compared to the IPI> 2 to 3 year OS p
ISSN:0350-199X
1986-5961
DOI:10.5455/medarh.2016.70.342-347