Crystal structure of vilazodone hydro-chloride methanol monosolvate

In the title compound, C H N O ·Cl ·CH OH {systematic name: 4-(2-carbamoyl-1-benzo-furan-5-yl)-1-[4-(5-cyano-1 -indol-3-yl)but-yl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicular to the benzo-fur...

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Bibliographic Details
Published in:Acta crystallographica. Section E, Crystallographic communications Crystallographic communications, 2016-12, Vol.72 (Pt 12), p.1783-1785
Main Authors: Hu, Xiu-Rong, Ye, Jia-Li, Gu, Jian-Ming
Format: Article
Language:English
Subjects:
Research Communications
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Summary:In the title compound, C H N O ·Cl ·CH OH {systematic name: 4-(2-carbamoyl-1-benzo-furan-5-yl)-1-[4-(5-cyano-1 -indol-3-yl)but-yl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicular to the benzo-furan ring system, with a dihedral angle of 85.77 (2)°. In the crystal, the organic cations, Cl anions and methanol solvent mol-ecules are linked by classical N-H⋯O and N-H⋯Cl hydrogen bonds, and weak C-H⋯O and C-H⋯π inter-actions into a three-dimensional supra-molecular architecture.
ISSN:2056-9890
2056-9890
DOI:10.1107/S2056989016017734