Conducting polymer-based multilayer films for instructive biomaterial coatings

To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. F...

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Bibliographic Details
Published in:Future science OA 2015-11, Vol.1 (4), p.FSO79-FSO79
Main Authors: Hardy, John G, Li, Hetian, Chow, Jacqueline K, Geissler, Sydney A, McElroy, Austin B, Nguy, Lindsey, Hernandez, Derek S, Schmidt, Christine E
Format: Article
Language:English
Subjects:
Preliminary Communication
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Summary:To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues.
ISSN:2056-5623
2056-5623
DOI:10.4155/fso.15.79