Comparison of cortisol and thyroid hormones between tuberculosis-suspect and healthy elephants of Nepal

We compared cortisol and thyroid hormone (T3 and T4) concentrations between tuberculosis (TB)-suspected (n=10) and healthy (n=10) elephants of Nepal. Whole blood was collected from captive elephants throughout Nepal, and TB testing was performed using the ElephantTB STAT-PAK® and DPP VetTB® serologi...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2016, Vol.78(11), pp.1713-1716
Main Authors: PAUDEL, Sarad, BROWN, Janine L., THAPALIYA, Sharada, DHAKAL, Ishwari P., MIKOTA, Susan K., GAIRHE, Kamal P., SHIMOZURU, Michito, TSUBOTA, Toshio
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Bacterial - blood
Antigens, Bacterial - blood
Antigens, Bacterial - immunology
Asian elephant
Cortisol
Elephants
Female
Hormones
Hydrocortisone - blood
Immunoassays
Immunoenzyme Techniques
Mycobacterium bovis - immunology
Mycobacterium tuberculosis - immunology
Nepal
Thyroid gland
Thyroid hormones
Thyroxine
Thyroxine - blood
Triiodothyronine
Triiodothyronine - blood
Tuberculosis
Tuberculosis, Pulmonary - immunology
Tuberculosis, Pulmonary - physiopathology
Tuberculosis, Pulmonary - veterinary
Wildlife Science
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Summary:We compared cortisol and thyroid hormone (T3 and T4) concentrations between tuberculosis (TB)-suspected (n=10) and healthy (n=10) elephants of Nepal. Whole blood was collected from captive elephants throughout Nepal, and TB testing was performed using the ElephantTB STAT-PAK® and DPP VetTB® serological assays that detect antibodies against Mycobacterium tuberculosis and M. bovis in elephant serum. Cortisol, T3 and T4 were quantified by competitive enzyme immunoassays, and the results showed no significant differences in hormone concentrations between TB-suspect and healthy elephants. These preliminary data suggest neither adrenal nor thyroid function is altered by TB disease status. However, more elephants, including those positively diagnosed for TB by trunk wash cultures, need to be evaluated over time to confirm results.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.16-0212