Positive association between serum apolipoprotein M levels and hepatitis B virus DNA load in HBeAg-negative chronic hepatitis B

Hepatitis virus B (HBV) has infected millions of people worldwide. Notably, such infections can be associated with hepatic complications. Levels of apolipoprotein M (apoM), a component of high-density lipoprotein (HDL), are known to be significantly elevated in patients with chronic hepatitis B (CHB...

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Bibliographic Details
Published in:Lipids in health and disease 2016-12, Vol.15 (1), p.210-210, Article 210
Main Authors: Shen, Ting, Wu, Wei Min, Du, Wen Han, Wang, Lin, He, La Gu, Tan, Li, Wang, ZeYou, Chen, Ruohong, Hu, Min, Ren, Ya Ping
Format: Article
Language:English
Subjects:
Adult
Analysis
Apolipoproteins
Apolipoproteins - blood
DNA, Viral - blood
Female
Genetic aspects
Health aspects
Hepatitis B
Hepatitis B e Antigens
Hepatitis B virus - immunology
Hepatitis B, Chronic - blood
Hepatitis B, Chronic - immunology
Humans
Male
Middle Aged
Physiological aspects
Viral Load
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Summary:Hepatitis virus B (HBV) has infected millions of people worldwide. Notably, such infections can be associated with hepatic complications. Levels of apolipoprotein M (apoM), a component of high-density lipoprotein (HDL), are known to be significantly elevated in patients with chronic hepatitis B (CHB). The aim of this study was to investigate the relationship between HBV DNA load in serum and serum apoM levels in patients with CHB. A total of 73 HBeAg-negative CHB patients, 50 HBeAg-positive CHB patients, and 79 non-CHB controls were included in the study cohort. The age and body mass index (BMI) of the study participants were matched. Serum levels of apoM and the HBV antigens HBsAg and HBeAg were measured by enzyme-linked immunosorbent assay (ELISA) analysis. Serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST), cholesterol, and triglycerides (TG) were assessed using an automatic biochemical analyzer. Serum HBV DNA levels were quantified by real-time PCR analysis. Data were analyzed by Spearman's rank correlation coefficient, Pearson correlation coefficient, and multivariate linear regression model (continuous variables), or Student's t-test (mean differences). Both the HBeAg-negative CHB and HBeAg-positive CHB patient groups exhibited elevated serum levels of apoM. Moreover, serum apoM levels were positively correlated with serum HBV DNA levels in HBeAg-negative CHB patients (r = 0.394, p 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-016-0384-3