MiR-196a regulates heme oxygenase-1 by silencing Bach1 in the neonatal mouse lung

In the lung, heme oxygenase-1 (HO-1) is developmentally regulated, with its highest expression in the first days of life. In addition, neonatal mice have limited HO-1 induction in hyperoxia compared with adults. However, few reports have addressed the functional effect of microRNAs (miRNAs) in the r...

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Published in:American journal of physiology. Lung cellular and molecular physiology 2016-08, Vol.311 (2), p.L400-L411
Main Authors: Go, Hayato, La, Ping, Namba, Fumihiko, Ito, Masato, Yang, Guang, Brydun, Andrey, Igarashi, Kazuhiko, Dennery, Phyllis A
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Animals
Animals, Newborn
Basic-Leucine Zipper Transcription Factors - genetics
Basic-Leucine Zipper Transcription Factors - metabolism
Bronchopulmonary Dysplasia - enzymology
Cells, Cultured
Gene expression
Gene Expression Regulation, Developmental
Gene Expression Regulation, Enzymologic
Heme Oxygenase-1 - genetics
Heme Oxygenase-1 - metabolism
Lung - enzymology
Lung - growth & development
Lungs
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mice, Inbred C57BL
Mice, Knockout
MicroRNAs - metabolism
MicroRNAs - physiology
Ribonucleic acid
RNA
RNA Interference
RNA, Messenger - genetics
RNA, Messenger - metabolism
Rodents
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Summary:In the lung, heme oxygenase-1 (HO-1) is developmentally regulated, with its highest expression in the first days of life. In addition, neonatal mice have limited HO-1 induction in hyperoxia compared with adults. However, few reports have addressed the functional effect of microRNAs (miRNAs) in the regulation of HO-1 in vivo. The aims of the present study were to characterize changes in lung miRNA expression during postnatal development and in response to hyperoxic exposure, and to identify miRNAs that target lung HO-1 gene expression. Neonatal (
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00428.2015