Losing your GRP on platelet activation

In this issue of Blood , Kato et al identify compound heterozygous mutations in the Ras guanyl releasing protein 2 ( RASGRP2 ) gene that cause decelerated platelet signaling, reduced platelet aggregation under shear stress, and severe bleeding in an adolescent patient. 1

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Bibliographic Details
Published in:Blood 2016-12, Vol.128 (23), p.2597-2598
Main Author: Holly, Stephen P.
Format: Article
Language:English
Subjects:
Enzyme Activation
Humans
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Platelet Activation
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Description
Summary:In this issue of Blood , Kato et al identify compound heterozygous mutations in the Ras guanyl releasing protein 2 ( RASGRP2 ) gene that cause decelerated platelet signaling, reduced platelet aggregation under shear stress, and severe bleeding in an adolescent patient. 1
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2016-10-742742