Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs

Azomethine‐linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4‐oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1H‐NMR, 13C‐NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer c...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2016-11, Vol.53 (6), p.1871-1877
Main Authors: Mochona, Bereket, Jackson, Timothy, McCauley, DeCoria, Mazzio, Elizabeth, Redda, Kinfe K.
Format: Article
Language:English
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Summary:Azomethine‐linked pyrrole bishetarylazoles containing benzimidazole/pyrazolone/1,3,4‐oxadiazole were synthesized in satisfactory yields. Their structures were confirmed by IR, 1H‐NMR, 13C‐NMR, and elemental analysis. Evaluation for the cytotoxic activities in vitro against a panel of breast cancer cell lines (MDA‐AB‐231, BT‐474, and Ishikawa cells) revealed that the pyrrole–benzimidazole hybrids are more potent than the pyrazolone and 1,3,4‐oxadiazole hybrids in all cell lines. Compound 9 displayed promising cytotoxicity against BT‐474 cell line with IC50 values, 7.7 µM.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2501