High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells

Highlights • MN1 expression is significantly increased in TEL–AML1+ B-ALL patients bone marrow. • MN1 and AML1 expression show significant correlation in B-ALL patients. • Ectopic MN1 increases colony forming activity of mouse Pro-B/Pre-B cells.

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Bibliographic Details
Published in:Leukemia research 2015-08, Vol.39 (8), p.906-912
Main Authors: Numata, Masashi, Yener, Mehmet Deniz, Ekmekçi, Sema Sırma, Aydın, Müge, Grosveld, Gerard, Cardone, Monica, Terranova, Sabrina, Geltink, Ramon Klein, Özbek, Uğur, Özçelik, Emrah, Güleç, Çağrı, Anak, Sema, Karaman, Serap, Öztürk, Gülyüz, Akbıyık, Meral, Kandilci, Ayten
Format: Article
Language:English
Subjects:
Adolescent
ALL
AML1
Animals
B-Lymphocytes - physiology
Bone Marrow Cells - metabolism
Bone Marrow Cells - physiology
Case-Control Studies
Cells, Cultured
Child
Child, Preschool
Colony-Forming Units Assay
Female
Gene Expression Regulation, Leukemic
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cells - metabolism
Hematopoietic Stem Cells - physiology
Humans
Infant
Male
Mice
Mice, Inbred C57BL
MN1
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology
Primary Cell Culture
TEL–AML1
Tumor Suppressor Proteins - genetics
Young Adult
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Description
Summary:Highlights • MN1 expression is significantly increased in TEL–AML1+ B-ALL patients bone marrow. • MN1 and AML1 expression show significant correlation in B-ALL patients. • Ectopic MN1 increases colony forming activity of mouse Pro-B/Pre-B cells.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.05.013