PD-L1+MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment

Myeloid-derived suppressor cells (MDSCs) could have important roles in immune regulation, and MDSCs can be induced in patients with various malignant tumors. The immune-suppressive functions of MDSCs in hepatocellular carcinoma (HCC) patients have not been clarified. Therefore, we tried to analyze t...

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Bibliographic Details
Published in:Scientific reports 2016-12, Vol.6 (1), p.39296-39296, Article 39296
Main Authors: Iwata, Tomoaki, Kondo, Yasuteru, Kimura, Osamu, Morosawa, Tatsuki, Fujisaka, Yasuyuki, Umetsu, Teruyuki, Kogure, Takayuki, Inoue, Jun, Nakagome, Yu, Shimosegawa, Tooru
Format: Article
Language:English
Subjects:
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Aged
Arsenic
B7-H1 Antigen - analysis
Blood Cells - chemistry
Blood Cells - immunology
Carcinoma, Hepatocellular - pathology
Cell Count
Cells, Cultured
Coculture Techniques
Color
Female
Flow Cytometry
Hepatocellular carcinoma
Hepatocytes
Humanities and Social Sciences
Humans
Immunoregulation
Japan
Leukocytes, Mononuclear - chemistry
Leukocytes, Mononuclear - immunology
Liver cancer
Liver Neoplasms - pathology
Macrophage colony-stimulating factor
Male
Middle Aged
multidisciplinary
Myeloid-Derived Suppressor Cells - chemistry
Myeloid-Derived Suppressor Cells - immunology
PD-L1 protein
Peripheral blood
Science
Suppressor cells
Tumor cell lines
Tumor Microenvironment
Tumors
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Summary:Myeloid-derived suppressor cells (MDSCs) could have important roles in immune regulation, and MDSCs can be induced in patients with various malignant tumors. The immune-suppressive functions of MDSCs in hepatocellular carcinoma (HCC) patients have not been clarified. Therefore, we tried to analyze the biological significance of MDSCs in HCC patients. We quantified PD-L1 + MDSCs of HCC patients in various conditions by using multi-color flow cytometry analysis. PBMCs from HCC patients contained significantly higher percentages of PD-L1 + MDSCs in comparison to those from healthy subjects ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/srep39296