The prognostic performance of Adjuvant! Online and Nottingham Prognostic Index in young breast cancer patients

Background: Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients. Methods: This multicentre hospital-based retrospective cohort study included young (⩽40 years) and older (55–60 years) breast cancer p...

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Bibliographic Details
Published in:British journal of cancer 2016-12, Vol.115 (12), p.1471-1478
Main Authors: Lambertini, Matteo, Pinto, Ana Catarina, Ameye, Lieveke, Jongen, Lynn, Del Mastro, Lucia, Puglisi, Fabio, Poggio, Francesca, Bonotto, Marta, Floris, Giuseppe, Van Asten, Kathleen, Wildiers, Hans, Neven, Patrick, de Azambuja, Evandro, Paesmans, Marianne, Azim Jr, Hatem A
Format: Article
Language:English
Subjects:
692/699/67/1347
692/700/1750/1976
692/700/565/1436/99
Accuracy
Adult
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - pathology
Cancer Research
Cancer therapies
Clinical Study
Cohort analysis
Drug Resistance
Epidemiology
Female
Hospitals
Humans
Medical prognosis
Medical records
Medical research
Middle Aged
Molecular Medicine
Oncology
Pathology
Patients
Prognosis
Review boards
Survival Analysis
Womens health
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Summary:Background: Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients. Methods: This multicentre hospital-based retrospective cohort study included young (⩽40 years) and older (55–60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient. Tools ability to predict outcomes (i.e., calibration) and their discriminatory accuracy was assessed. Results: The study included 1283 patients, 376 young and 907 older women. Adjuvant! Online accurately predicted 10-year OS (absolute difference: 0.7%; P =0.37) in young cohort, but overestimated 10-year DFS by 7.7% ( P =0.003). In older cohort, AOL significantly underestimated both 10-year OS and DFS by 7.2% ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2016.359