PLGA‐PNIPAM Microspheres Loaded with the Gastrointestinal Nutrient NaB Ameliorate Cardiac Dysfunction by Activating Sirt3 in Acute Myocardial Infarction

Acute myocardial infarction (AMI) is the death of cardiomyocytes caused by a lack of energy due to ischemia. Nutrients supplied by the blood are the main source of cellular energy for cardiomyocytes. Sodium butyrate (NaB), a gastrointestinal nutrient, is a short‐chain fatty acid (butyric acid) that...

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Published in:Advanced science 2016-12, Vol.3 (12), p.1600254-n/a
Main Authors: Cheng, Panke, Zeng, Wen, Li, Li, Huo, Da, Zeng, Lingqing, Tan, Ju, Zhou, Jingting, Sun, Jiansen, Liu, Ge, Li, Yanzhao, Guan, Ge, Wang, Yuxin, Zhu, Chuhong
Format: Article
Language:English
Subjects:
Angiogenesis
Autophagy
Cardiomyocytes
Drug delivery systems
Energy
Fatty acids
Heart attacks
Hypoxia
Ischemia
Metabolism
microspheres
Nutrients
Ostomy
Physiology
Polymers
R&D
Research & development
Sirt3
Sodium
Temperature
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Summary:Acute myocardial infarction (AMI) is the death of cardiomyocytes caused by a lack of energy due to ischemia. Nutrients supplied by the blood are the main source of cellular energy for cardiomyocytes. Sodium butyrate (NaB), a gastrointestinal nutrient, is a short‐chain fatty acid (butyric acid) that may act as an energy source in AMI therapy. Poly(lactic‐co‐glycolic acid)‐Poly (N‐isopropylacrylamide) microspheres loaded with NaB (PP‐N) are synthesized to prolong the release of NaB and are injected into ischemic zones in a Sprague–Dawley rat AMI model. Here, this study shows that PP‐N can significantly ameliorate cardiac dysfunction in AMI, and NaB can specially bind to Sirt3 structure, activating its deacetylation ability and inhibiting the generation of reactive oxygen species, autophagy, and angiogenesis promotion. The results indicate that NaB, acting as a nutrient, can protect cardiomyocytes in AMI. These results suggest that the gastrointestinal nutrient NaB may be a new therapy for AMI treatment, and PP‐N may be the ideal therapeutic regimen. The novel gastrointestinal nutrient NaB is loaded by Poly(lactic‐co‐glycolic acid)‐Poly (N‐isopropylacrylamide) microspheres and injected into the ischemic site for acute myocardial infarction treatment. The deacetylation ability of Sirt3 is enhanced by NaB through binding to special structure in Sirt3, followed by the inhibition of reactive oxygen species generation and the initiation of autophagy as well angiogenesis, contributing to cardiac dysfunction amelioration.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.201600254