Non-antibiotic treatments for bacterial diseases in an era of progressive antibiotic resistance

The emergence of multi-drug resistant (MDR) microbial pathogens threatens the very foundation upon which standard antibacterial chemotherapy is based. We must consider non-antibiotic solutions to manage invasive bacterial infections. Transition from antibiotics to non-traditional treatments poses re...

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Bibliographic Details
Published in:Critical care (London, England) England), 2016-12, Vol.20 (1), p.397-397, Article 397
Main Author: Opal, Steven M
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Carbapenems
Care and treatment
Complications and side effects
Critical care
Drug resistance
Ebola virus
Health aspects
Immunotherapy
Infections
Infectious diseases
Microbial drug resistance
Polyclonal antibodies
Toxins
Vaccines
Viruses
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Summary:The emergence of multi-drug resistant (MDR) microbial pathogens threatens the very foundation upon which standard antibacterial chemotherapy is based. We must consider non-antibiotic solutions to manage invasive bacterial infections. Transition from antibiotics to non-traditional treatments poses real clinical challenges that will not be easy to solve. Antibiotics will continue to reliably treat some infections (e.g., group A streptococci and Treponema pallidum) but will likely need adjuvant therapies or will need to be replaced for many bacterial infections in the future.
ISSN:1364-8535
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-016-1549-1