Pathways in external apical root resorption associated with orthodontia

Structured Author –  Hartsfield JK Jr. To review studies investigating if genetic factors play a role in external apical root resorption (EARR) during orthodontic treatment. Heritability estimation in human sib‐pairs, comparison of multiple inbred mouse strains, human sib‐pair linkage and parents‐ch...

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Published in:Orthodontics & craniofacial research 2009-08, Vol.12 (3), p.236-242
Main Author: Hartsfield Jr, JK
Format: Article
Language:English
Subjects:
Animals
Dentistry
Disease Models, Animal
Diseases in Twins
Genetic Linkage - genetics
Genetic Predisposition to Disease
Humans
interleukin-1beta
Interleukin-1beta - genetics
Linkage Disequilibrium - genetics
Mice
Mice, Inbred Strains
Mice, Knockout
Microsatellite Repeats - genetics
orthodontics
Orthodontics, Corrective - adverse effects
osteoprotegerin
Osteoprotegerin - genetics
P2XR7
Receptor Activator of Nuclear Factor-kappa B - genetics
Receptors, Purinergic P2 - genetics
Receptors, Purinergic P2X7
root resorption
Root Resorption - genetics
Tooth Apex - pathology
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Summary:Structured Author –  Hartsfield JK Jr. To review studies investigating if genetic factors play a role in external apical root resorption (EARR) during orthodontic treatment. Heritability estimation in human sib‐pairs, comparison of multiple inbred mouse strains, human sib‐pair linkage and parents‐child trio association studies, and two gene (Il‐1b, and P2rx7) knock out mouse models. Heritability for EARR of the maxillary central incisors concurrent with orthodontic treatment is 0.8. DBA/2J, BALB/cJ, and 129P3/J inbred mouse strains are highly susceptible (p 
ISSN:1601-6335
1601-6343
DOI:10.1111/j.1601-6343.2009.01458.x