Interferon-Tau has Antiproliferative effects, Represses the Expression of E6 and E7 Oncogenes, Induces Apoptosis in Cell Lines Transformed with HPV16 and Inhibits Tumor Growth In Vivo

• Published in: Journal of Cancer 2016-01, Vol.7 (15), p.2231-2240
• Main Authors: Padilla-Quirarte, Herbey Oswaldo, Trejo-Moreno, Cesar, Fierros-Zarate, Geny, Castañeda, Jhoseline Carnalla, Palma-Irizarry, Marie, Hernández-Márquez, Eva, Burguete-Garcia, Ana Isabel, Peralta-Zaragoza, Oscar, Madrid-Marina, Vicente, Torres-Poveda, Kirvis, Bermúdez-Morales, Victor Hugo
• Format: Article
• Language: English
• Subjects: Research Paper
• ISSN: 1837-9664; 1837-9664
• DOI: 10.7150/jca.15502

Interferon tau (IFN-τ) is a promising alternative antiviral and immunotherapeutic agent in a wide variety of diseases including infectious, neurodegenerative, autoimmune and cancer due to its low toxicity in comparison with other type I interferon´s. The objective of our study was established the effect of the bovine IFN-τ on human (SiHa) and murine (BMK-16/myc) cells transformed with HPV 16 and evaluates the antitumor effect in a murine tumor model HPV 16 positive. We determine that bovine IFN-τ has antiproliferative effects, pro-apoptotic activity and induces repression of viral E6 and E7 oncogenes (time- and dose-dependent) on human and murine cells transformed with HPV 16 similar to the effects of IFN-β. However, IFN-τ induces greater antiproliferative effect, apoptosis and repression of both oncogenes in BMK-16/myc cells compared to SiHa cells. The differences were explained by the presence and abundance of the type I interferon receptor in each cell line. On the other hand, we treated groups of tumor-bearing mice (HPV16 positive) with IFN-τ and showed the inhibition tumor growth effect . Our finding indicates that bovine IFN-τ may be a good candidate for immunotherapy against cervical cancer.