Choosing the right cell line for renal cell cancer research

Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understand...

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Bibliographic Details
Published in:Molecular cancer 2016-12, Vol.15 (1), p.83-83, Article 83
Main Authors: Brodaczewska, Klaudia K, Szczylik, Cezary, Fiedorowicz, Michal, Porta, Camillo, Czarnecka, Anna M
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Cancer
Carcinoma, Renal cell
Carcinoma, Renal Cell - drug therapy
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Care and treatment
Cell Line, Tumor
Cell lines
Diagnosis
Drug Screening Assays, Antitumor
Genetic aspects
Humans
Kidney Neoplasms - drug therapy
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Models, Biological
Review
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Summary:Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established cell lines. Therefore, the proper use of in vitro models is crucial to enhance our understanding of cancer. Therapeutics against renal cell cancer (RCC) are also screened with the use of cell lines. Multiple RCC in vitro cultures are available, allowing in vivo heterogeneity in the laboratory, but at the same time, these can be a source of errors. In this review, we tried to sum up the data on the RCC cell lines used currently. An increasing amount of data on RCC shed new light on the molecular background of the disease; however, it revealed how much still needs to be done. As new types of RCC are being distinguished, novel cell lines and the re-exploration of old ones seems to be indispensable to create effective in vitro tools for drug screening and more.
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-016-0565-8