Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies

Previous observational studies have suggested a potential relationship between osteoarthritis (OA) and the risk of cardiovascular disease (CVD), with conflicting results. We aimed to provide a systematic and quantitative summary of the association between OA and the risk of CVD. We searched Medline...

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Bibliographic Details
Published in:Scientific reports 2016-12, Vol.6 (1), p.39672-39672, Article 39672
Main Authors: Wang, Haoran, Bai, Jing, He, Bing, Hu, Xinrong, Liu, Dongliang
Format: Article
Language:English
Subjects:
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Arthritis
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Female
Health risk assessment
Health risks
Humanities and Social Sciences
Humans
Male
Meta-analysis
multidisciplinary
Observational studies
Observational Studies as Topic
Osteoarthritis
Osteoarthritis - epidemiology
Prospective Studies
Regression Analysis
Research Design
Retrospective Studies
Risk Factors
Science
Sensitivity analysis
Sensitivity and Specificity
Stroke - epidemiology
Studies
Treatment Outcome
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Summary:Previous observational studies have suggested a potential relationship between osteoarthritis (OA) and the risk of cardiovascular disease (CVD), with conflicting results. We aimed to provide a systematic and quantitative summary of the association between OA and the risk of CVD. We searched Medline and EMBASE to retrieve prospective and retrospective studies that reported risk estimates of the association between OA status and CVD risk. Pooled estimates were calculated by a random effects model. The search yielded 15 articles including a total of 358,944 participants, including 80,911 OA patients and 29,213 CVD patients. Overall, the risk of CVD was significantly increased by 24% (RR: 1.24, 95% CI: 1.12 to 1.37, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep39672